Proteins at Work
large scale analysis of proteins
and their interactions in relation to biological functions

Partners

Prof. Dr. Albert Heck - Utrecht University
Heck is Professor at Utrecht University and Head of the Biomolecular Mass Spectrometry & Proteomics group of since September 1998. The general theme of the research in his group is to develop and implement innovative mass spectrometric methods for the more efficient and detailed characterization of protein and other biomolecules in relation to their biological function. The emphasis is on the structural characterization of proteins and post-translational modifications as well as on the investigation of protein complexes and protein interactions important in e.g. protein folding, protein ligand binding, and the formation of tertiary and quaternary structures. Albert Heck is scientific director of the Netherlands Proteomics Centre and coordinator of both the European proteomics infrastructure PRIME-XS and of Proteins At Work.

Prof. Dr. Hans Clevers - Hubrecht Institute
Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. 
From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht. Since 2012 he is President of the Royal Netherlands Academy of Arts a
nd Sciences (KNAW).
Albert J. R. 

Prof. Dr. Geert Kops - University Medical Center Utrecht
Geert Kops is Professor of Molecular Tumor Cell Biology in a shared appointment between the department of Molecular Cancer Research and department of Medical Oncology, at the University Medical Center Utrecht, The Netherlands. He obtained his PhD in 2001 at Utrecht University for his investigations into the PI3kinase-PKB/Akt–FOXO pathway and its role in cellular proliferation. He then pursued postdoctoral studies in the lab of Don Cleveland at the Ludwig Institute for Cancer Research in La Jolla, California, where he investigated aspects of the mitotic checkpoint. He returned to the Netherlands in 2005. His primary research interests include signaling networks that regulate chromosome segregation, and the potential use of targeting these networks as an anti-cancer strategy.

Prof. Dr. Ben Scheres - Wageningen University
Ben Scheres is Professor at Wageningen University. In 1997, he was given the Young Chemist Prize and a pioneer grant from NWO (Netherlands Organization for Scientific Research). The American Botanical Society awarded the highly prestigious Siron Pelton Prize to him in 2000. Professor Scheres received the NWO-Spinoza Prize in 2006 for his major contributions to the understanding of cell development in plants, and in particular for his new insights into the role of stem cells in root development. 

Prof. Dr. Rene Medema - Netherlands Cancer Institute
Rene Medema was Professor of Experimental Oncology at the UMC Utrecht from 2004 until 2011, when he moved to Amsterdam to become the Scientific Director of the Netherlands Cancer Institute. His research focusses on biomedicine with broad emphasis on cell cycle regulation and cell cycle checkpoints. He is particularly interested in the mechanisms that protect genomic integrity and the defects therein in human cancer.

Prof. Dr. Roland Kanaar - Erasmus Medical Center Rotterdam
Roland Kanaar is Professor of Molecular Radiation Genetics at the Erasmus MC Rotterdam since 2000. His current research addresses the mechanisms and biological relevance of genome surveillance processes with particular emphasis on homologous DNA recombination and DNA double-strand break repair. Genome surveillance is essential to prevent chromosomal abnormalities, which in their turn may lead to hereditary diseases, cancer or cell decay.  He is a scientific co-founder of the biotechnology company DNage, which is focused on the development of products for medical and health problems associated with ageing.

Proteins At Work is a programme of the Netherlands Proteomics Centre and is made possible by NWO and Utrecht University

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