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Nature publication on adult stem cells

Nature publication on adult stem cells

August, 2011

In a recent Nature publication the Clevers research group and proteomics experts from the Netherlands Proteomics Centre (NPC) established crucial associations between adult stem cell markers and some important signaling molecules in stem cell development.

Hans Clevers, director of the Hubrecht Institute, says: 'Intitally our research was focused on immunology and was chiefly DNA-oriented. However, when you want to discover the function of genes you need to study its proteins and interactions with other molecules. Using new proteomics techniques was a great leap into the unknown for us, but could not have happened without the NPC.


Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling

Wim de Lau, Nick Barker, Teck Y. Low, Bon-Kyoung Koo, Vivian S. W. Li, Hans Teunissen, Pekka Kujala, Andrea Haegebarth, Peter J. Peters, Marc van de Wetering, D. E. Stange, J. van Es, Daniele Guardavaccaro, Richard B. M. Schasfoort, Yasuaki Mohri, Katsuhiko Nishimori, Shabaz Mohammed, Albert J. R. Heck & Hans Clevers

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